This therapeutic candidate also carries an exosomal protein

Codiak Bio’s IPO Brings In $82M as Exosome Clinical Trials Begin
  Codiak BioSciences now has $82.5 million to fund clinical tests of a new class of medicines based on exosomes, tiny bubbles formed by cells that the company harnesses to carry therapeutic cargo. Late Tuesday, Codiak priced its offering of 5.5 million shares at $15 apiece, the midpoint of its projected $14 to $16 per share price range. Shares of the Cambridge, MA-based biotech are set to begin trading Wednesday on the Nasdaq under the stock symbol “CDAK.” Exosomes are extracellular vesicles that function like a messaging system between cells. Laden with proteins, genetic material, and other substances, these vesicles transport molecules from one cell to another, altering the function of the cell that receives the cargo. Codiak’s technology engineers exosomes to carry therapeutic molecules, either inside the vesicle or on its surface. The Codiak IPO comes with clinical trials now underway for two programs. A month ago, the company began a Phase 1 study of exoIL-12, which is designed to to carry interleukin 12 (IL-12), a cytokine, on the exosome’s surface. Research of the cytokine has found that while experimental cytokine therapies targeted tumors, they also had effects on healthy tissue, particularly the liver. Codiak’s exoIL-12 is intended to limit its effects to the area immediately around a tumor. After evaluating ascending doses in healthy volunteers, Codiak says its Phase 1 study will move on to test the therapy in patients with cutaneous T cell lymphoma. Preliminary results from the first part of the study are expected by the end of this year, according to the company’s IPO filing. At the start of October, Codiak began dosing patients in a Phase 1 study of exoSTING, an exosome engineered with therapeutic molecules on the inside of the vesicle. These molecules are intended to hit the stimulator of interferon genes (STING) pathway of the innate immune system to prompt an inflammatory response to cancer. This therapeutic candidate also carries an exosomal protein on the surface of the engineered exosome to facilitate uptake by tumor cells. The company plans to test exoSTING as a treatment for solid tumors. Preliminary data from the study are expected by the middle of next year. https://new.c.mi.com/ph/post/266769 https://new.c.mi.com/ph/post/266071 https://new.c.mi.com/ph/post/266839 https://new.c.mi.com/ph/post/265418 https://new.c.mi.com/ph/post/268135 https://new.c.mi.com/ph/post/266081 https://new.c.mi.com/ph/post/265207 https://new.c.mi.com/ph/post/266844 https://new.c.mi.com/ph/post/265423 https://new.c.mi.com/ph/post/266849 https://new.c.mi.com/ph/post/265212 https://new.c.mi.com/ph/post/265217 https://new.c.mi.com/ph/post/266769/RedditStreamS_FIFA_World_Cup_Live_StreamReddit_ON_ https://new.c.mi.com/ph/post/266071/beIN_SPORTS_Netherlands_vs_Argentina_Live_Stream%F0%9D%9A%81 https://new.c.mi.com/ph/post/266839/FREE_STREAMING_Watch_Netherlands_vs_Argentina_Live https://new.c.mi.com/ph/post/265418/Netherlands_vs_Argentina_Live_Stream_Reddit__Crack https://new.c.mi.com/ph/post/268135/Reddit_FIFA_World_Cup_2022_StreamS_-_Argentina_vs_ https://new.c.mi.com/ph/post/266081/TOTAL_SPORTEK_Argentina_vs_Netherlands_Free_LIVE_S https://new.c.mi.com/ph/post/265207/Blacktie_Sports_-_Free_Reddit_Netherlands_vs_Argen https://new.c.mi.com/ph/post/266844/RedditStreamS_Argentina_vs_Netherlands_Live_Stream https://new.c.mi.com/ph/post/265423/CrackstreamsNetherlands_vs_Argentina_Live_StreamRe https://new.c.mi.com/ph/post/266849/OfficialRedditFIFA_World_Cup_Netherlands_vs_Argent https://new.c.mi.com/ph/post/265212/++RedditStreamS_Netherlands_vs_Argentina_Live_Stre https://new.c.mi.com/ph/post/265217/%F0%9D%90%8B%F0%9D%90%88%F0%9D%90%95%F0%9D%90%84%F0%9D%90%92%F0%9D%90%93%F0%9D%90%91%F0%9D%90%84%F0%9D%90%80%F0%9D%90%8CTV_Argentina_vs_Netherlands_Li https://techplanet.today/post/reddit-fifa-world-cup-2022-streams-argentina-vs-netherlands-live-stream-at-reddit-2022 https://techplanet.today/post/free-streaming-watch-netherlands-vs-argentina-live-streaming-at-broadcast-09-december-2022 https://techplanet.today/post/youtube-tv-netherlands-vs-argentina-free-live-stream-120922 https://techplanet.today/post/netherlands-vs-argentina-live-stream-reddit-crackstreams-reddit-stream-and-buffstream-alternatives https://www.exoltech.us/wall/forum/topic/12795 http://beterhbo.ning.com/profiles/blogs/asdfsadsfdfsadsdfg http://taylorhicks.ning.com/photo/albums/sadsfdfsadsfdfg https://www.onfeetnation.com/profiles/blogs/asdfsadsfdfgadsfdfg https://tophsffootball.shivtr.com/forum_threads/3727292 http://www.liknti.com/threads/asfdgfgdasfdgfghadsfg.544677/ http://allabouturanch.com/forum/topics/sadsfdfgadsfdfsadsdf http://playit4ward-sanantonio.ning.com/photo/albums/adsdsadsfdf https://stationfm.ning.com/photo/albums/sadsdsadsfdf-1 https://theprose.com/post/548861/adsfdfgsadsfdfg https://mcspartners.ning.com/photo/albums/sasdfadsfdfg-2 http://www.shadowville.com/board/general-discussions/watch-online-free-664#p572294 https://webhitlist.com/profiles/blogs/sfdfadsfdfgadsfdfgdasfdgfg http://www.scientix.eu/es_ES/web/scientix-cop-4/topic-1/-/message_boards/message/1299633 https://star.shivtr.com/forum_threads/3727293 https://ameblo.jp/amberhard07/entry-12778297238.html https://challonge.com/zprkjskr https://caribbeanfever.com/photo/albums/asdfsadsfdfsadsdf http://zacriley.ning.com/photo/albums/adsfdfsadfsadsfdf https://dev.bukkit.org/paste/be99091d https://www.posteezy.com/adsdbv-asdbv-badsfdfbv-badsfdfg https://guides.co/g/adsfdfadsfdfgadsfd/257576 https://www.vingle.net/posts/5057681 http://community.getvideostream.com/topic/105261/dscv-adsdcv-ascv-asdfv https://vocal.media/stories/dfb-asdvb-ascbv-adsdfbvb https://www.ign.com/account/playlist/lists/asdv-badsfdvb-adsfdvb-advb-adsfdgf https://www.hybrid-analysis.com/sample/d1eb450656eedc184b31706c5b340f1fdba1e1f0a163a5d1ecc705353b4cd1e7 https://www.hybrid-analysis.com/sample/57fb36ac60bda70606e290885b42229f27c9f858e79b95bb0d54d851b75fc97b https://www.hybrid-analysis.com/sample/c2236d81b298e540a2236b65b5fa124b70464f19f7f7a262396308c103eec741 https://www.hybrid-analysis.com/sample/fea03b234f2930e2a20ab36afaa4efc62e6a703cbb7a96caf47ea24583726025 https://www.hybrid-analysis.com/sample/baa5aa7bbda7b74875c2f2cc93351960f38ddce42174e7869fc2f3696e3c7f43 Cancer therapies are also the focus of a partnership that Codiak started last year with Jazz Pharmaceuticals (NASDAQ: JAZZ). Earlier this year, the biotech began an alliance with Sarepta Therapeutics (NASDAQ: SRPT) focused on using the exosome technology to develop new muscle medicines.

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