Pharmacotherapy A Pathophysiologic Approach Dipiro Pdf 13

Pharmacotherapy A Pathophysiologic Approach Dipiro Pdf 13


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Pharmacotherapy A Pathophysiologic Approach Dipiro Pdf 13

Pharmacotherapy: A Pathophysiologic Approach will help you advance the quality of patient care through evidence-based medication therapy derived from sound pharmacotherapeutic principles. The scope of this trusted classic goes beyond drug indications and dosages to include the initial selection, proper administration, and monitoring of drugs. You will find everything you need to provide safe, effective drug therapy across the full range of therapeutic categories.

The pharmacologic management of mild to moderate dementia should focus on minimizing the symptoms of cognitive dysfunction, thus improving the quality of life. The basis for pharmacologic interventions for dementia involves several steps: (i) comprehensive screening for, and assessment of, the underlying cause(s); (ii) optimization of potential risk factors; and (iii) pharmacologic intervention for cognitive and noncognitive symptoms. Two approaches that have demonstrated efficacy in improving cognition in patients with mild to moderate dementia are acetylcholinesterase inhibitors and the NMDA receptor antagonist memantine. These are the drugs of first and second choice, respectively. Treatment of neuropsychiatric symptoms in patients with dementia should focus on minimizing the severity of the symptoms and helping the patient to participate in meaningful activities. Several newer pharmacologic agents that have shown efficacy in treating neuropsychiatric symptoms are discussed in this chapter.

A single prescription pill may provide a minor benefit for one patient, but can be fatal for another. As a general rule, the appropriate drug selection and therapy regimen should be individualized for each patient. The pharmacotherapy section of this lesson explains how to select and use the most appropriate medication to treat a particular disease condition. The available information about disease treatments in the preceding chapters can guide you in treatment decisions when a medication is indicated. For drugs that lack evidence-based clinical information, review questions provide a framework for critiquing the quality of available evidence. To more fully understand drug efficacy, adverse effects, adverse drug interactions, drug interactions, cost effectiveness, and drug safety, discuss these topics in a forum of peers to learn more about current treatment options and their problems with implementation.

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