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Direct injection of liposomes and mono-antibody conjugate for highly sensitive tumor-targeted MRI. This article describes a method to incorporate, in a simple manner, a fluorescent dye, labeled dextran-microbeads, and quantum dots (QDs) into liposomes to enhance the sensitivity and to improve the properties of magnetic resonance imaging (MRI) for tumor-targeted imaging. Laser-induced polymerization of the liposome/dye-labeled dextran-microbeads/QDs system was applied to the liposome membrane. The liposomes were injected intravenously into mice via a tail vein and accumulated in the tumor through EPR (enhanced permeability and retention) effect. The liposome membrane was found to be useful for both encapsulating liposomes and incorporating different contents, such as magnetic beads, quantum dots, or dye-labeled dextran-microbeads. Hence, the liposome/dye-labeled dextran-microbeads/QDs system is a candidate as a drug delivery vehicle for MRI-guided therapeutic drugs, MRI-targeted theranostics, or imaging in vivo in a highly sensitive manner.At a basic level, the Universe is a dynamic collection of very simple things, like a planet in orbit around a star. When we study a planet in orbit we observe that it follows a predictable path, but we can’t measure the path with high precision. The planets’ path is caused by the gravitational pull of all the other planets, as well as by the motion of the sun. In fact, everything is made up of individual particles, some of which are identical to other particles. As a result, the Earth is continually in a state of motion, moving around the sun. It is our ability to measure the trajectory of the Earth relative to the sun that enables us to understand and predict the gravitational effects. From this we can use the acceleration caused by gravity to calculate the mass of the Earth. And the mass of the Earth is related to the velocity of the sun. From this information, we can work out a very complicated equation which says that the size of a planet is related to how far it is from the sun. But the size of a planet is not what we care about. For that we need to make a step further. What do we care about? We care about how the Earth will continue to orbit the sun in the long run. There are two factors which will influence the path of the Earth. The first is gravity, and the second is inertia. Gravity is the force that causes the Earth to lose energy, as it moves around the sun. Without this force, the Earth would continue to orbit the sun in the same way that it orbits now, moving in a loop around the sun. Inertia is the resistance to change.




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